Alphanumerical Visual Display Made Of Dna Logic Gates For Drug Susceptibility Testing Of Pathogens

Keywords

deoxyribozymes; DNA logic gates; G-quadruplexes; peroxidases; rifampin susceptibility

Abstract

Molecular diagnostics of drug-resistant pathogens require the analysis of point mutations in bacterial or viral genomes, which is usually performed by trained professionals and/or by sophisticated computer algorithms. We have developed a DNA-based logic system that autonomously analyzes mutations found in the genome of Mycobacterium tuberculosis complex (MTC) bacteria and communicates the output to a human user as alphanumeric characters read by the naked eye. The five-gate system displays “O” (“no infection”) for the absence of MTC infection and “P” or “F” for passing or failing a drug-susceptibility test, respectively.

Publication Date

2-2-2018

Publication Title

ChemBioChem

Volume

19

Issue

3

Number of Pages

203-206

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1002/cbic.201700626

Socpus ID

85041349308 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85041349308

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