Internal Interaction Changes Within The Mutation Of Slc26A4 Stas Domain

Keywords

DFNB4; Molecular dynamics; Network analysis; PDS; Pendrin (SLC26A4)

Abstract

Pendrin (SLC26A4) is a protein associated with the auditory system. Pendred syndrome (PDS) and DFNB4 are typical auditory disorders caused by mutations in the SLC26A4 STAS domain. We generated an SLC26A4 STAS domain model and six mutated STAS domain models related to PDS, DFNB4, and PDS/DFNB4 by homology modeling. Molecular dynamics simulation was performed to find the equilibration conformation and fluctuation information. Using fluctuation information, we calculated betweenness centrality and edge betweenness to reveal communication between secondary structures of STAS domain. The edge betweenness results showed that mutated models generate communication signals that are less clear than WT models.

Publication Date

10-16-2018

Publication Title

Chemical Physics Letters

Volume

710

Number of Pages

226-233

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.cplett.2018.09.002

Socpus ID

85053122115 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85053122115

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