Biologically-Inspired Microphysiological Systems

Keywords

Body-on-a-chip; Human-on-a-chip; Microphysiological system; Multi-organ device; Organ-on-a-chip

Abstract

Microphysiological multi-organ devices are designed to mimic the physiological interaction of various interconnected organ models, by successfully imitating organismal functionality and response to substances. The first concepts of in vitro multi-organ systems were put forward in the late 1980s, demonstrating that such systems could provide mechanistic insight into toxicology questions. In 2010, governmental grants and initiatives in Europe and the United States strongly accelerated the development of microphysiological systems. The rapid increase in the number of laboratories and spin-off companies working on these devices, and the commitment of big pharma and cosmetics companies, has led to the generation of a diversity of systems for various applications. In conjunction with regulatory science-driven efforts, high-quality data derived from these devices laid the foundation for later qualification studies. Further advancements to include more organs and functionalities lead the way toward systemic micro-organisms on a chip - so-called body-on-a-chip devices. These systems will eventually establish a completely new substance testing paradigm.

Publication Date

10-22-2018

Publication Title

The History of Alternative Test Methods in Toxicology

Number of Pages

279-285

Document Type

Article; Book Chapter

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/B978-0-12-813697-3.00030-5

Socpus ID

85072261221 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85072261221

This document is currently not available here.

Share

COinS