An Overview Of Polyamine Metabolism In Pancreatic Ductal Adenocarcinoma

Keywords

metabolism; pancreatic ductal adenocarcinoma; polyamine transport; polyamines

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest major cancers, with a five year survival rate of less than 8%. With current therapies only giving rise to modest life extension, new approaches are desperately needed. Even though targeting polyamine metabolism is a proven anticancer strategy, there are no reports, which thoroughly survey the literature describing the role of polyamine biosynthesis and transport in PDAC. This review seeks to fill this void by describing what is currently known about polyamine metabolism in PDAC and identifies new targets and opportunities to treat this disease. Due to the pleiotropic effects that polyamines play in cells, this review covers diverse areas ranging from polyamine metabolism (biosynthesis, catabolism and transport), as well as the potential role of polyamines in desmoplasia, autophagy and immune privilege. Understanding these diverse roles provides the opportunity to design new therapies to treat this deadly cancer via polyamine depletion.

Publication Date

5-15-2018

Publication Title

International Journal of Cancer

Volume

142

Issue

10

Number of Pages

1968-1976

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1002/ijc.31155

Socpus ID

85037983760 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85037983760

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