Towards Sustainable Diagnostics: Replacing Unstable H2O2 By Photoactive Tio2 In Testing Systems For Visible And Tangible Diagnostics For Use By Blind People

Creator

Yulia V. Lanchuk, Saint Petersburg National Research University of Information Technologies, Mechanics and Optics University ITMO
Sviatlana A. Ulasevich, Saint Petersburg National Research University of Information Technologies, Mechanics and Optics University ITMO
Tatiana A. Fedotova, University of Central Florida
Dmitry M. Kolpashchikov, Saint Petersburg National Research University of Information Technologies, Mechanics and Optics University ITMO
Ekaterina V. Skorb, Saint Petersburg National Research University of Information Technologies, Mechanics and Optics University ITMO

Abstract

Blind and color blind people cannot use colorimetric diagnostics; the problem is especially severe in rural areas where high temperatures and the absence of electricity challenge modern diagnostics. Here we propose to replace the unstable component of a diagnostic test, H2O2, with stable TiO2. Under UV irradiation, TiO2 forms reactive oxygen species that initiate polymerization of acrylamide causing liquid-to-gel transition in an analyte-dependent manner. We demonstrate that specific DNA sequences can be detected using this approach. This development may enable the detection of biological molecules by users with limited resources, for example in developing countries or for travelers in remote areas.

Publication Date

1-1-2018

Publication Title

RSC Advances

Volume

8

Issue

66

Number of Pages

37735-37739

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1039/c8ra06711b

Copyright Status

Unknown

Socpus ID

85056816121 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85056816121

STARS Citation

Lanchuk, Yulia V.; Ulasevich, Sviatlana A.; Fedotova, Tatiana A.; Kolpashchikov, Dmitry M.; and Skorb, Ekaterina V., "Towards Sustainable Diagnostics: Replacing Unstable H2O2 By Photoactive Tio2 In Testing Systems For Visible And Tangible Diagnostics For Use By Blind People" (2018). Scopus Export 2015-2019. 9674.
https://stars.library.ucf.edu/scopus2015/9674