Title

Papio Spp. Colon Microbiome And Its Link To Obesity In Pregnancy

Keywords

baboon; microbiome; obesity; pregnancy

Abstract

Introduction: Gut microbial communities are critical players in the pathogenesis of obesity. Pregnancy is associated with increased bacterial load and changes in gut bacterial diversity. Sparse data exist regarding composition of gut microbial communities in obesity combined with pregnancy. Material and methods: Banked tissues were collected under sterile conditions during necropsy, from three non-obese (nOb) and four obese (Ob) near-term pregnant baboons. Sequences were assigned taxonomy using the Ribosomal Database Project classifier. Microbiome abundance and its difference between distinct groups were assessed by a nonparametric test. Results: Three families predominated in both the nOb and Ob colonic microbiome: Prevotellaceae (25.98% and 32.71% respectively), Ruminococcaceae (12.96% and 7.48%), and Lachnospiraceae (8.78% and 11.74%). Seven families of the colon microbiome displayed differences between Ob and nOb groups. Conclusion: Changes in gut microbiome in pregnant obese animals open the venue for dietary manipulation in pregnancy.

Publication Date

12-1-2018

Publication Title

Journal of Medical Primatology

Volume

47

Issue

6

Number of Pages

393-401

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1111/jmp.12366

Socpus ID

85056330124 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85056330124

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