Identification Of A Sorbicillinoid-Producing Aspergillus Strain With Antimicrobial Activity Against Staphylococcus Aureus: A New Polyextremophilic Marine Fungus From Barents Sea

Keywords

Antimicrobial activity; Aspergillus protuberus; Bisvertinolone; Marine fungi; MDR; Sediments

Abstract

The exploration of poorly studied areas of Earth can highly increase the possibility to discover novel bioactive compounds. In this study, the cultivable fraction of fungi and bacteria from Barents Sea sediments has been studied to mine new bioactive molecules with antibacterial activity against a panel of human pathogens. We isolated diverse strains of psychrophilic and halophilic bacteria and fungi from a collection of nine samples from sea sediment. Following a full bioassay-guided approach, we isolated a new promising polyextremophilic marine fungus strain 8Na, identified as Aspergillusprotuberus MUT 3638, possessing the potential to produce antimicrobial agents. This fungus, isolated from cold seawater, was able to grow in a wide range of salinity, pH and temperatures. The growth conditions were optimised and scaled to fermentation, and its produced extract was subjected to chemical analysis. The active component was identified as bisvertinolone, a member of sorbicillonoid family that was found to display significant activity against Staphylococcus aureus with a minimum inhibitory concentration (MIC) of 30 μg/mL.

Publication Date

8-1-2018

Publication Title

Marine Biotechnology

Volume

20

Issue

4

Number of Pages

502-511

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1007/s10126-018-9821-9

Socpus ID

85045247622 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85045247622

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