Faculty Advisor

Kersten Schroeder

Keywords

Chronic kidney disease (CKD); focal segmental glomerulosclerosis (FSGS); non-hypertensive CKD; non-diabetic CKD; estimated glomerular filtration rate (EGFR); NHANES

Abstract

Background. Several studies have reported the link between diabetes, cardiovascular disease, hypertension, and obesity as risk factors for the onset of chronic kidney disease (CKD), ultimately leading to renal replacement therapies such as dialysis and kidney transplantation. Although extensively researched in adults aged 55 years and older, CKD remains under-researched for young adults. Despite its emergence as a healthcare concern, limited data exists on risk factors impacting young adults without major comorbidities.

Objective. This research study aims to understand the potential risk factors unique to this population, seeking to guide prevention strategies and improve prognosis in already diagnosed individuals. Additionally, the research explores how socioeconomic and demographic variables influence CKD and its associated healthcare burden.

Methods. Using data from the National Health and Nutrition Examination Survey (NHANES) from cycles 2013-2018, the analysis focuses on individuals with non-diabetic, non-hypertensive CKD. Quantitative methods are employed to evaluate the impact of comorbidities, lifestyle behaviors, and socioeconomic indicators on CKD and the broader healthcare system.

Results. Weighted analysis of NHANES 2013–2018 data revealed that young adults with hypertension and diabetes had significantly higher prevalence of advanced CKD stages. In non-diabetic and non-hypertensive participants, obesity, abnormal waist circumference, low income, and race were significantly associated with higher CKD risk.

Conclusions. These findings highlight a growing burden in the healthcare system, even in the absence of traditional factors. The targeted preventive measures are vital in the early screening of non-diabetic and non-hypertensive individuals.

Date Added

8-2025

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