Abstract

The ability to engineer noble-metal nanostructures (NMNSs) in a controllable manner and to understand the structure-dependent properties greatly boost our knowledge in rational design of biosensing technologies. In particular, as a type of highly efficient peroxidase mimics, NMNSs hold promising potential to break through the bottleneck of conventional enzyme-based in vitro diagnostics. During the time of my Ph.D. study, I have successfully: 1) directed a two-step method involving seed-mediated growth and chemical etching for the synthesis of Ru nanoframes (RuNFs) with face-centered cubic crystal phase and enhanced catalytic activities; 2) demonstrated, for the first time, the inherent peroxidase-like activity of RuNFs as a type of efficient peroxidase mimics, opening up possibilities for their bioapplications; 3) developed an enzyme-free signal amplification technique for ultrasensitive colorimetric assay of disease biomarkers by using Pd-Ir nanooctahedra encapsulated gold vesicles as labels; 4) prepared polyvinylpyrrolidone (PVP)-capped Pt nanocubes with superior peroxidase-like catalytic activity and record-high specific catalytic activity; 5) developed a facile colorimetric method for the detection of Ag(I) ions with picomolar sensitivity by using the PVP-capped Pt nanocubes as the probes; 6) developed a non-enzyme cascade amplification strategy for colorimetric assay of disease biomarkers by taking advantage of the interaction between the Ag(I) ions and PVP-capped Pt nanocubes; and 7) established a highly sensitive colorimetric lateral flow assay platform by using Au@Pt core-shell nanoparticles as the labels that possess both plasmonic and catalytic properties.

Notes

If this is your thesis or dissertation, and want to learn how to access it or for more information about readership statistics, contact us at STARS@ucf.edu

Graduation Date

2019

Semester

Spring

Advisor

Xia, Xiaohu

Degree

Doctor of Philosophy (Ph.D.)

College

College of Sciences

Department

Chemistry

Degree Program

Chemistry

Format

application/pdf

Identifier

CFE0007559

URL

http://purl.fcla.edu/fcla/etd/CFE0007559

Language

English

Release Date

May 2019

Length of Campus-only Access

None

Access Status

Doctoral Dissertation (Open Access)

Download

Included in

Chemistry Commons

Share

COinS