Tuning Multiple Motor Travel via Single Motor Velocity
Abbreviated Journal Title
cargo travel; kinesin; multiple-motor transport; transport regulation; velocity; TUG-OF-WAR; MICROTUBULE-BASED MOTILITY; CYTOPLASMIC DYNEIN; KINESIN; MOTORS; INTRACELLULAR-TRANSPORT; VESICLE TRANSPORT; FORCE GENERATION; MOLECULAR MOTORS; CARGO TRANSPORT; IN-VITRO; Cell Biology
Microtubule-based molecular motors often work in small groups to transport cargos in cells. A key question in understanding transport (and its regulation in vivo) is to identify the sensitivity of multiple-motor-based motion to various single molecule properties. Whereas both single-motor travel distance and microtubule binding rate have been demonstrated to contribute to cargo travel, the role of single-motor velocity is yet to be explored. Here, we recast a previous theoretical study, and make explicit a potential contribution of velocity to cargo travel. We test this possibility experimentally, and demonstrate a strong negative correlation between single-motor velocity and cargo travel for transport driven by two motors. Our study thus discovers a previously unappreciated role of single-motor velocity in regulating multiple-motor transport.
"Tuning Multiple Motor Travel via Single Motor Velocity" (2012). Faculty Bibliography 2010s. 3512.