Tuning Multiple Motor Travel via Single Motor Velocity

    Authors

    J. Xu; Z. Y. Shu; S. J. King;S. P. Gross

    Comments

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    Abbreviated Journal Title

    Traffic

    Keywords

    cargo travel; kinesin; multiple-motor transport; transport regulation; velocity; TUG-OF-WAR; MICROTUBULE-BASED MOTILITY; CYTOPLASMIC DYNEIN; KINESIN; MOTORS; INTRACELLULAR-TRANSPORT; VESICLE TRANSPORT; FORCE GENERATION; MOLECULAR MOTORS; CARGO TRANSPORT; IN-VITRO; Cell Biology

    Abstract

    Microtubule-based molecular motors often work in small groups to transport cargos in cells. A key question in understanding transport (and its regulation in vivo) is to identify the sensitivity of multiple-motor-based motion to various single molecule properties. Whereas both single-motor travel distance and microtubule binding rate have been demonstrated to contribute to cargo travel, the role of single-motor velocity is yet to be explored. Here, we recast a previous theoretical study, and make explicit a potential contribution of velocity to cargo travel. We test this possibility experimentally, and demonstrate a strong negative correlation between single-motor velocity and cargo travel for transport driven by two motors. Our study thus discovers a previously unappreciated role of single-motor velocity in regulating multiple-motor transport.

    Journal Title

    Traffic

    Volume

    13

    Issue/Number

    9

    Publication Date

    1-1-2012

    Document Type

    Article

    Language

    English

    First Page

    1198

    Last Page

    1205

    WOS Identifier

    WOS:000307724900002

    ISSN

    1398-9219

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