Buffer-Stable ChitosanPolyglutamic Acid Hybrid Nanoparticles for Biomedical Applications
Abbreviated Journal Title
biodegradation; biohybrid materials; buffer-stable; chitosan; polyelectrolytes; GAMMA-GLUTAMIC ACID; CHITOSAN NANOPARTICLES; DRUG-DELIVERY; WEAK; POLYELECTROLYTES; MOLECULAR-WEIGHT; DEGRADATION RATES; THIN-FILMS; IN-VITRO; MULTILAYERS; TRANSITIONS; Biochemistry & Molecular Biology; Materials Science, Biomaterials; Polymer Science
In spite of their attractive features, widespread biomedical applications of CS nanoparticles are yet to be realized due to their poor stability in physiological conditions, such as in buffer system at pH 7.4. Buffer-stable chitosan-based hybrid NPs (HNPs) are reported and characterized. Buffer stability is achieved by introducing polyglutamic acid to chitosan. The effect of PGA to CS molar ratio and crosslinking on HNP integrity, buffer stability, and biodegradability are studied. Preliminary in vitro studies are carried out to evaluate targeted uptake efficiency of folate conjugated HNPs. Successful demonstration of buffer stability and cancer cell targeting by HNPs achieves important milestones for chitosan-based nanoparticle technology.
"Buffer-Stable ChitosanPolyglutamic Acid Hybrid Nanoparticles for Biomedical Applications" (2013). Faculty Bibliography 2010s. 4367.