Title

Buffer-Stable ChitosanPolyglutamic Acid Hybrid Nanoparticles for Biomedical Applications

Authors

Authors

A. Malhotra; X. L. Zhang; J. Turkson;S. Santra

Comments

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Abbreviated Journal Title

Macromol. Biosci.

Keywords

biodegradation; biohybrid materials; buffer-stable; chitosan; polyelectrolytes; GAMMA-GLUTAMIC ACID; CHITOSAN NANOPARTICLES; DRUG-DELIVERY; WEAK; POLYELECTROLYTES; MOLECULAR-WEIGHT; DEGRADATION RATES; THIN-FILMS; IN-VITRO; MULTILAYERS; TRANSITIONS; Biochemistry & Molecular Biology; Materials Science, Biomaterials; Polymer Science

Abstract

In spite of their attractive features, widespread biomedical applications of CS nanoparticles are yet to be realized due to their poor stability in physiological conditions, such as in buffer system at pH 7.4. Buffer-stable chitosan-based hybrid NPs (HNPs) are reported and characterized. Buffer stability is achieved by introducing polyglutamic acid to chitosan. The effect of PGA to CS molar ratio and crosslinking on HNP integrity, buffer stability, and biodegradability are studied. Preliminary in vitro studies are carried out to evaluate targeted uptake efficiency of folate conjugated HNPs. Successful demonstration of buffer stability and cancer cell targeting by HNPs achieves important milestones for chitosan-based nanoparticle technology.

Journal Title

Macromolecular Bioscience

Volume

13

Issue/Number

5

Publication Date

1-1-2013

Document Type

Article

Language

English

First Page

603

Last Page

613

WOS Identifier

WOS:000319331100010

ISSN

1616-5187

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