Buffer-Stable ChitosanPolyglutamic Acid Hybrid Nanoparticles for Biomedical Applications

    Authors

    A. Malhotra; X. L. Zhang; J. Turkson;S. Santra

    Comments

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    Abbreviated Journal Title

    Macromol. Biosci.

    Keywords

    biodegradation; biohybrid materials; buffer-stable; chitosan; polyelectrolytes; GAMMA-GLUTAMIC ACID; CHITOSAN NANOPARTICLES; DRUG-DELIVERY; WEAK; POLYELECTROLYTES; MOLECULAR-WEIGHT; DEGRADATION RATES; THIN-FILMS; IN-VITRO; MULTILAYERS; TRANSITIONS; Biochemistry & Molecular Biology; Materials Science, Biomaterials; Polymer Science

    Abstract

    In spite of their attractive features, widespread biomedical applications of CS nanoparticles are yet to be realized due to their poor stability in physiological conditions, such as in buffer system at pH 7.4. Buffer-stable chitosan-based hybrid NPs (HNPs) are reported and characterized. Buffer stability is achieved by introducing polyglutamic acid to chitosan. The effect of PGA to CS molar ratio and crosslinking on HNP integrity, buffer stability, and biodegradability are studied. Preliminary in vitro studies are carried out to evaluate targeted uptake efficiency of folate conjugated HNPs. Successful demonstration of buffer stability and cancer cell targeting by HNPs achieves important milestones for chitosan-based nanoparticle technology.

    Journal Title

    Macromolecular Bioscience

    Volume

    13

    Issue/Number

    5

    Publication Date

    1-1-2013

    Document Type

    Article

    Language

    English

    First Page

    603

    Last Page

    613

    WOS Identifier

    WOS:000319331100010

    ISSN

    1616-5187

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