Application Of In Vivo Flow Profiling To Stented Human Coronary Arteri
Blood flow dynamics, CFD, Wall shear stress, Coronary arteries, Drug eluting stents, 3D reconstruction
The study applies in vivo technique for profiling hemodynamics and wall shear stress (WSS) distribution in human coronary arteries. The methodology involves fusion of 2D Intra Vascular Ultra Sound and Bi-plane angiograms to reproduce the 3D arterial geometry. This geometry is then used in a Computational Fluid Dynamics (CFD) module for flow modeling. The Walburn and Schneck constitutive relation was used to represent the non-Newtonian blood rheology. The methodology is applied to study the relationship between WSS and Neointimal Hyperplasia (NIH) in two groups of diabetic patients after being treated separately with bare metal stents (BMS) and Sirolimus Eluting Stents (SES). The stent assignments were blinded until the end of the study. The study was repeated for the patients after 9 months. The predicted WSS ranged from (0.1- 8 N/m2) and was categorized into five classes: low ( < 1 N/m2); low-normal (1-2 N/m2); normal (2-3 N/m2); high-normal (3-4 N/m2); high ( > 4 N/m2). The results indicate NIH in 5 of the patients treated with BMS and none in SES cases. These results correlate with our predicted WSS distribution.
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Master of Science (M.S.)
College of Engineering and Computer Science
Mechanical, Materials, and Aerospace Engineering
Length of Campus-only Access
Masters Thesis (Open Access)
Nanda, Hitesh, "Application Of In Vivo Flow Profiling To Stented Human Coronary Arteri" (2004). Electronic Theses and Dissertations. 216.