Raman Spectroscopic Study Of Single Red Blood Cells Infected By The Malaria Parasite Plasmodium Falciparum
Raman, Malaria, Plasmodium, Falciparum
Raman micro-spectroscopy provides a non-destructive probe with potential applications as a diagnostic tool for cellular disorders. This study presents micro-Raman spectra of live erythrocytes infected with a malaria parasite and investigates the potential of this probe to monitor molecular changes which occur during differentiation of the parasite inside the cell. At an excitation wavelength of 633 nm the spectral bands are dominated by hemoglobin vibrations yielding information the on structure and spin state of the heme moiety. It also demonstrates the novel use of silica capillaries as a viable method for studying the erythrocytes in an environment that is much closer to their native state, thus opening the possibility of maintaining the cell in vivo for long periods to study the dynamics of the parasite's growth.
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Master of Science (M.S.)
College of Sciences
Length of Campus-only Access
Masters Thesis (Open Access)
Carter, William, "Raman Spectroscopic Study Of Single Red Blood Cells Infected By The Malaria Parasite Plasmodium Falciparum" (2007). Electronic Theses and Dissertations. 3110.