High intensity interval training, [beta] hydroxy [beta] methylbutyrate, aerobic, endurance, vo2peak, respiratory compensation point, ventilatory threshold


Purpose: To examine the effects of 28 days of β-hydroxy-β-methylbutyrate free acid (HMB) and high-intensity interval training (HIIT) on maximal oxygen consumption (VO2peak), ventilatory threshold (VT), respiratory compensation point (RCP) and time to exhaustion (Tmax) in collegeaged men and women. Methods: Healthy men and women (n=34, age and VO2peak= 22.7+3.1yr and 39.3+5.0 mL. kg-1.min-1, respectively) participated in this study. All participants completed a series of tests prior and subsequent to treatment. A maximal oxygen consumption test was performed on a cycle ergometer to assess VO2peak, Tmax, VT, and RCP. The peak power output (Ppeak), power at VT (PVT) and power at RCP (PRCP) were also recorded from this test. Twenty-six subjects completed 12 HIIT (80-120% maximal workload) exercise sessions consisting of 5-6 bouts of a 2:1 minute cycling work to rest ratio protocol over a four-week period, while eight served as controls (CTL). In double-blind fashion, the HIIT groups were assigned into either a placebo (HIIT) or 3g per day of HMB (HMB-HIIT). Body composition was measured with dual energy x-ray absorptiometry (DEXA). Outcomes were assessed by ANCOVA with posttest means adjusted for pretest differences. Results: The HMB-HIIT intervention showed significant (p & lt 0.05) gains in VO2peak, VT, and PVT versus the CTL and HIIT group. Both HIIT and HMB-HIIT treatment groups demonstrated significant (p < 0.05) improvement over CTL for Ppeak, Tmax, RCP, and PRCP with no significant difference between the treatment groups. There were no significant differences observed for any measures of body composition. An independent-samples t-test confirmed that there were no significant differences between the training volumes for the HIIT and HMB-HIIT groups. Conclusion: These findings suggest that the addition of HMB supplementation may result in greater changes in VO2peak and VT than HIIT alone. Therefore, in college-aged men and women, the use of HMB supplementation may enhance the benefits of HIIT on aerobic performance measures.


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Graduation Date





Stout, Jeffrey


Doctor of Philosophy (Ph.D.)


College of Education and Human Performance

Degree Program

Education; Exercise Physiology








Release Date

May 2017

Length of Campus-only Access

3 years

Access Status

Doctoral Dissertation (Open Access)


Dissertations, Academic -- Education and Human Performance; Education and Human Performance -- Dissertations, Academic