Abstract

The endothelium is among the most mechanically enriched environments in the body. It is exposed to a range of hemodynamic-induced and extracellular forces. Of these extracellular forces, the migration of leukocytes through the endothelium will contribute both to classic immune response and development of certain pathologies. While the path of migration across the endothelium will depend on leukocyte and vascular bed type, recent evidence has suggested that the intercellular mechanical microenvironment and forces are also equally as important to this process. Therefore, we present here a model that mimics specific physiological states of a stagnant hemodynamic flow in which we hypothesize that leukocytes will demonstrate attachment preferences to particular areas of differing intercellular stresses on the endothelial bed. Using a model such as this one, it may be possible to exploit these intercellular stresses when developing macrophage-targeted therapies.

Notes

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Graduation Date

2020

Semester

Spring

Advisor

Steward, Robert

Degree

Master of Science (M.S.)

College

College of Graduate Studies

Degree Program

Interdisciplinary Studies

Format

application/pdf

Identifier

CFE0007910; DP0023044

URL

https://purls.library.ucf.edu/go/DP0023044

Language

English

Release Date

May 2020

Length of Campus-only Access

None

Access Status

Masters Thesis (Open Access)

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