Abstract
The objective of this dissertation was to develop novel methods of patterning inorganic and organic materials, develop biocompatibility evaluations, and subsequently apply these methods toward developing biosensors and lab-on-a-chip devices, such as Interdigitated Electrodes (IDEs) and Microelectrode Arrays (MEAs) on non-traditional (such as nanostructured and plasmonic) polymer substrates or deploy these methods to enhance precision cellular placement on traditional (glass) MEA substrates. It was hypothesized that a combination of such facile microfabrication techniques and patterning technologies on traditional and non-traditional substrates would increase the sensitivity and selectivity of such sensor platforms by several orders of magnitude, and potentially introduce new modalities for cell-based biosensing. In order to demonstrate the biological functionality of these new IDEs and MEAs, a variety of cell cultures were used (cardiac, stem cell, and endothelial cells) to study the growth, proliferation, modes of increasing sensitivity and response to various compounds in vitro (outside the body).
Notes
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Graduation Date
2020
Semester
Fall
Advisor
Rajaraman, Swaminathan
Degree
Doctor of Philosophy (Ph.D.)
College
College of Engineering and Computer Science
Department
Materials Science and Engineering
Degree Program
Materials Science and Engineering
Format
application/pdf
Identifier
CFE0008772;DP0025503
URL
https://purls.library.ucf.edu/go/DP0025503
Language
English
Release Date
6-15-2021
Length of Campus-only Access
None
Access Status
Doctoral Dissertation (Open Access)
STARS Citation
Hart, Cacie, "Development of Facile Microfabrication Technologies for the Fabrication and Characterization of Multimodal Impedimetric, Plasmonic, and Electrophysiological Biosensors" (2020). Electronic Theses and Dissertations, 2020-2023. 801.
https://stars.library.ucf.edu/etd2020/801