Keywords

HFpEF, Diastolic Dysfunction, Atrial Systole, Diastolic Pressure Volume Relationship, Myocardial deformation, Material Parameters

Abstract

Cardiovascular diseases remain a major public health concern worldwide, with heart failure emerging as a significant contributor to morbidity and mortality. Among heart failure cases, Heart Failure with preserved Ejection Fraction (HFpEF) presents a substantial clinical challenge due to its poor understanding and diagnostic complexity. Despite its prevalence, HFpEF lacks accurate diagnostic tools, hindering effective prognosis and therapy planning. This study addresses the knowledge gap surrounding HFpEF and diastolic dysfunction by focusing on the passive myocardial response during atrial systole, a critical yet understudied aspect of cardiac function. Current clinical measures, such as left ventricular ejection fraction, have limitations in assessing HFpEF and diastolic dysfunction due to their lack of specificity and focus on active myocardial contraction. Additionally, existing studies on myocardial deformation primarily evaluate ventricular systole, overlooking the passive response during atrial systole. This study proposes to characterize the passive myocardial response by investigating left ventricular deformation during atrial systole and integrating motion data with intraventricular pressure to estimate myocardial material properties. By enhancing our understanding of the passive myocardium, this research aims, in the future, to enable more accurate diagnosis and therapy planning for patients affected by diastolic dysfunction and HFpEF.

Completion Date

2024

Semester

Spring

Committee Chair

Perotti, Luigi

Degree

Doctor of Philosophy (Ph.D.)

College

College of Engineering and Computer Science

Department

Mechanical and Aerospace Engineering

Degree Program

Mechanical Engineering

Format

application/pdf

Language

English

Rights

In copyright

Release Date

November 2024

Length of Campus-only Access

None

Access Status

Doctoral Dissertation (Open Access)

Campus Location

Orlando (Main) Campus

Accessibility Status

Meets minimum standards for ETDs/HUTs

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