Keywords

Metallic Nanoparticles; In-vitro diagnostics; Lateral Flow Assay; Catalyst; LSPR

Abstract

The Lateral Flow Assay (LFA) represents one of the most classical in vitro detection platforms, wherein gold nanoparticles have emerged as the most extensively employed chromogenic agent. However, their utility has been hampered by their limited surface plasmonic resonance intensities, which have consistently constrained the detection sensitivity. Consequently, the adoption of alternative chromogenic agents or chromogenic schemes stands as a promising strategy for enhancing detection sensitivity of LFA. Transition metallic nanoparticles often exhibit inherently unique physical and chemical properties, by the modulation of their microstructures, we can endow them distinctive optical or catalytic properties. By integrating such engineered nanoparticles into the LFA platform, this holds significant promise for greatly elevating the sensitivity of detection.

Completion Date

2024

Semester

Spring

Committee Chair

Xia, Xiaohu

Degree

Doctor of Philosophy (Ph.D.)

College

College of Sciences

Department

Chemistry

Degree Program

Chemistry

Format

application/pdf

Language

English

Rights

In copyright

Release Date

November 2029

Length of Campus-only Access

5 years

Access Status

Doctoral Dissertation (Campus-only Access)

Campus Location

Orlando (Main) Campus

Accessibility Status

Meets minimum standards for ETDs/HUTs

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Restricted to the UCF community until November 2029; it will then be open access.

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