Keywords
Cerium Oxide, Tetravalence Cerium, Hydrolysis, Morphology Control
Abstract
Metal oxide nanoparticles constitute an important class of nanomaterials which has have received tremendous attention due to their distinct, specific activities comparison to their bulk. Among these, cerium oxide nanoparticles (CeNPs) have displayed outstanding promise across a wide range of applications owing to their unique redox properties. Given that the physical and chemical characteristics of nanomaterials are significantly influenced by their morphologies and sizes, the development of well-controlled synthesis methods for CeNPs holds great importance in both scientific research and industrial applications.
This dissertation seeks to peer into the formation of CeNPs in solution through wet chemical synthesis. Additionally, antioxidant properties of CeNPs were examined to explore the potential use of facet CeNPs in gene delivery and promoting wound healing for diabetic. The beginning of this work provides introduction and summary of some common concepts widely used in understanding of nanoparticles formation. In chapter two and three, the spontaneous hydrolysis behavior of tetravalent cerium salts in aqueous systems were studied in detail to understand the influence of synthesis condition on the nucleation kinetic and morphology evolution in the course of growth of nanoparticle. The results obtained from these studies offer constructive insights into designing a straightforward and controlled synthesis strategy for producing nanoclusters and faceted nanoparticles through wet chemical methods. Furthermore, in chapter five, we examine the impact of faceted CeNPs on biomolecule conjugation and their performance in gene delivery for the regulation of abnormal diabetic wound healing.
Overall, by taking advantage of the intrinsic properties of tetravalence cerium salt, this work highlights how manipulation of spontaneous hydrolysis could lead to formation of particles with different nanostructure and physicochemical properties.
Completion Date
2023
Semester
Fall
Committee Chair
Seal, Sudipta
Degree
Doctor of Philosophy (Ph.D.)
College
College of Engineering and Computer Science
Department
Materials Science and Engineering
Degree Program
Materials Science and Engineering
Format
application/pdf
Identifier
DP0028032
URL
https://purls.library.ucf.edu/go/DP0028032
Language
English
Release Date
December 2024
Length of Campus-only Access
1 year
Access Status
Doctoral Dissertation (Campus-only Access)
Campus Location
Orlando (Main) Campus
STARS Citation
Fu, Yifei, "Wet Chemical Synthesis of Cerium Oxide Nanoparticle and Biological Application" (2023). Graduate Thesis and Dissertation 2023-2024. 63.
https://stars.library.ucf.edu/etd2023/63
Restricted to the UCF community until December 2024; it will then be open access.