ORCID
0000-0001-9583-6676
Keywords
microphysiological systems, multi-organ, neuron, drug testing, disease modeling
Abstract
Microphysiological systems are a rapidly growing field of research for modeling of physiological processes and disease in an in vitro environment. The translatability and cost effectiveness of these platforms make them a valuable tool for drug discovery, allowing investigation of both efficacy and off-target toxicity either as a replacement or supplement to traditional animal models. Neurological disorders in particular are often difficult to emulate in an animal model, making the development of these models a highly useful area of research for both elucidation of brain function, as well as neurological disorders. Taking these models and integrating them into a multi-organ platform consisting of multiple interconnected organ models creates a valuable technology that can offer a comprehensive analysis of drug effects on the human body as a whole. The work presented here demonstrates the development of individual neuronal models, peripheral and nociceptive, as well as incorporation of a neuronal MPS into a multi-organ platform to investigate efficacy and off-target toxicity in a model of opioid overdose.
Completion Date
2025
Semester
Spring
Committee Chair
Guo, Xiufang
Degree
Doctor of Philosophy (Ph.D.)
College
College of Medicine
Department
Nanoscience Technology Center
Identifier
DP0029367
Document Type
Dissertation/Thesis
Campus Location
Orlando (Main) Campus
Subjects
Neuropharmacology--Research; Neurotoxicology--Research; Neurophysiology--Research; Toxicity testing--Research; Alternative toxicity testing
STARS Citation
Patel, Aakash, "Development of Human Neuronal Microphysiological Models and Subsequent Integration into Multi-Organ Platforms for Evaluation of Therapeutic Efficacy and Off-Target Toxicity" (2025). Graduate Thesis and Dissertation post-2024. 198.
https://stars.library.ucf.edu/etd2024/198
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