Sympathetic-Nerve Influence On Alveolar Type-Ii Cell Ultrastructure

    Authors

    D. J. Crittenden; L. A. Alexander;D. L. Beckman

    Comments

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    Abbreviated Journal Title

    Life Sci.

    Keywords

    PULMONARY SURFACTANT; LAMELLAR BODIES; MULTIVESICULAR BODIES; ALVEOLAR; TYPE II CELLS; RAT LUNG; SURFACTANT SECRETION; PULMONARY SURFACTANT; LAMELLAR BODIES; STIMULATION; PHOSPHOLIPIDS; RELEASE; Medicine, Research & Experimental; Pharmacology & Pharmacy

    Abstract

    Pulmonary surfactant release from lamellar bodies in alveolar type II cells in response to exogenous and circulating catecholamines is well documented but sympathetic influences from direct nerve stimulation are not as extensively studied. In older to study sympathetic nerve influence on release, ultrastructure of type II cells was examined following one min stimulation of the stellate ganglion (SGS) which sends sympathetic fibers to lung parenchyma. Type II cell secretion was assessed by measuring volume density of lamellar bodies, interpreting decreased volume density to indicate increased secretion according to accepted stereologic principles. The present study showed lamellar body volume density was I educed 20.8% in type II cells of SGS animals. Multivesicular body volume density was increased 150% by SGS, but Golgi bodies were unchanged. These data are consistent with type II cell origin of at least some of the increased saturated phospholipid recovered from airspaces in previous SGS studies, and support the view that sympathetic nerve activity may contribute to surfactant homeostasis under some conditions.

    Journal Title

    Life Sciences

    Volume

    55

    Issue/Number

    15

    Publication Date

    1-1-1994

    Document Type

    Article

    Language

    English

    First Page

    1229

    Last Page

    1235

    WOS Identifier

    WOS:A1994PE97500008

    ISSN

    0024-3205

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