Analysis Of The Genes Involved In Organizing The Tail Segments Of The Drosophila-Melanogaster Embryo

    Authors

    D. T. Kuhn; G. Turenchalk; J. A. Mack; G. Packert;T. B. Kornberg

    Comments

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    Abbreviated Journal Title

    Mech. Dev.

    Keywords

    DROSOPHILA EMBRYONIC DEVELOPMENT; TAIL SEGMENTS; HOMEOTIC GENES; ABDOMINAL-B GENE; BITHORAX-COMPLEX; HOMEOTIC GENE; REGULATORY FUNCTIONS; GOOSEBERRY LOCUS; EXPRESSION; PATTERN; PROTEIN; REGION; HEAD; Developmental Biology

    Abstract

    The metameric organization of the Drosophila melanogaster tail is obscured by developmental events that partially suppress or fuse some of its regions. To better define the developmental origins and segmental identities in the tail of the Drosophila embryo, we documented expression patterns and mutant phenotypes of several genes that play important roles in its morphogenesis. We documented the domains of engrailed (en), Abdominal-B (Abd-B) and caudal (cad) expression in the tail region. The staining pattern of cut (ct) was used to correlate the embryonic sense organs with their respective positions on the larval cuticle. The en patterns in different Bithorax-Complex (BX-C) Abd-B morphogenetic (m) and regulatory (r) mutants demonstrated that Abd-B functions to, among other things, suppress embryonic ventral epidermal structures on the posterior side of A8 to A9. Ventral epidermal structures were not added back into the en pattern in r(-) or BX-C- mutants, indicating that although the BX-C functions extend through A10, other non-BX-C genes must be required for development of this segment.

    Journal Title

    Mechanisms of Development

    Volume

    53

    Issue/Number

    1

    Publication Date

    1-1-1995

    Document Type

    Article

    Language

    English

    First Page

    3

    Last Page

    13

    WOS Identifier

    WOS:A1995RW55200001

    ISSN

    0925-4773

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