Title
How to Approach Alzheimer's Disease Therapy Using Stem Cell Technologies
Abbreviated Journal Title
J. Alzheimers Dis.
Keywords
Amyloid-beta protein precursor; mesenchymal stem cell; nanog; neuroreplacement; phenserine; AMYLOID PRECURSOR PROTEIN; PYRIMIDINE HETEROCYCLIC-COMPOUNDS; SEVERE; PARKINSONS-DISEASE; PLURIPOTENCY SUSTAINING FACTOR; FETAL-TISSUE-TRANSPLANTATION; EMBRYONIC DOPAMINE NEURONS; IN-UTERO; TRANSPLANTATION; CENTRAL-NERVOUS-SYSTEM; MARROW STROMAL CELLS; BONE-MARROW; Neurosciences
Abstract
The use of stem cells for neuroreplacement therapy is no longer science fiction-it is science fact. We have succeeded in producing neural cells in the brain using both neural and mesenchymal stem cell transplantation and even systemic injection using a small molecular compound. We have seen the improvement of cognitive function in animal models following the application of these stem cell technologies. These results may promise a bright future for stem cell based neuroreplacement therapies for neurodegenerative diseases including Alzheimer's disease (AD). However, we have to consider the pathophysiological environments of individual diseases before clinical applications can be introduced. We must find the factors in the pathology that may affect stem cell biology and overcome the negative effects on neuroreplacement. Here, we discuss not only the potential for therapeutic applications of stem cell strategies in neuropathological conditions, but also how to overcome the adverse effects on the biology of stem cells due to the factors that are altered under AD pathology.
Journal Title
Journal of Alzheimers Disease
Volume
15
Issue/Number
2
Publication Date
1-1-2008
Document Type
Review
Language
English
First Page
241
Last Page
254
WOS Identifier
ISSN
1387-2877
Recommended Citation
"How to Approach Alzheimer's Disease Therapy Using Stem Cell Technologies" (2008). Faculty Bibliography 2000s. 1021.
https://stars.library.ucf.edu/facultybib2000/1021
Comments
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