Title

Evidence for the effectiveness of botulinum toxin for spasmodic dysphonia from high-quality research designs

Authors

Authors

C. R. Watts; D. D. Truong;C. Nye

Comments

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Abbreviated Journal Title

J. Neural Transm.

Keywords

botulinum toxin; spasmodic dysphonia; LARYNGEAL DYSTONIA; INJECTION; THERAPY; MUSCLE; Clinical Neurology; Neurosciences

Abstract

The practice of evidence-based medicine promotes use of the knowledge ascertained from high quality research designs. The objective of this review was to determine what evidence has been provided from high quality research designs (e.g., randomized control trials or high quality prospective, matched group cohort studies), through December of 2006, relative to the effectiveness of botulinum toxin for treating spasmodic dysphonia. Results of the review indicated that no new high quality (Class I or Class II) studies have been published since 2001. One Class I study has been published since 1973, which found significant treatment effects for acoustic and perceptual variables of vocal function. Four Class II studies have been published during this same time frame, all finding significant treatment effects, though the nature of studied factors was variable between investigations. Based on the quality of evidence scale used, botulinum toxin can be considered an effective treatment for adductor spasmodic dysphonia.

Journal Title

Journal of Neural Transmission

Volume

115

Issue/Number

4

Publication Date

1-1-2008

Document Type

Article

Language

English

First Page

625

Last Page

630

WOS Identifier

WOS:000254878600010

ISSN

0300-9564

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