Evidence for the effectiveness of botulinum toxin for spasmodic dysphonia from high-quality research designs

    Authors

    C. R. Watts; D. D. Truong;C. Nye

    Comments

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    Abbreviated Journal Title

    J. Neural Transm.

    Keywords

    botulinum toxin; spasmodic dysphonia; LARYNGEAL DYSTONIA; INJECTION; THERAPY; MUSCLE; Clinical Neurology; Neurosciences

    Abstract

    The practice of evidence-based medicine promotes use of the knowledge ascertained from high quality research designs. The objective of this review was to determine what evidence has been provided from high quality research designs (e.g., randomized control trials or high quality prospective, matched group cohort studies), through December of 2006, relative to the effectiveness of botulinum toxin for treating spasmodic dysphonia. Results of the review indicated that no new high quality (Class I or Class II) studies have been published since 2001. One Class I study has been published since 1973, which found significant treatment effects for acoustic and perceptual variables of vocal function. Four Class II studies have been published during this same time frame, all finding significant treatment effects, though the nature of studied factors was variable between investigations. Based on the quality of evidence scale used, botulinum toxin can be considered an effective treatment for adductor spasmodic dysphonia.

    Journal Title

    Journal of Neural Transmission

    Volume

    115

    Issue/Number

    4

    Publication Date

    1-1-2008

    Document Type

    Article

    Language

    English

    First Page

    625

    Last Page

    630

    WOS Identifier

    WOS:000254878600010

    ISSN

    0300-9564

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