Drug/Dye-Loaded, Multifunctional Iron Oxide Nanoparticles for Combined Targeted Cancer Therapy and Dual Optical/Magnetic Resonance Imaging

    Authors

    S. Santra; C. Kaittanis; J. Grimm;J. M. Perez

    Abbreviated Journal Title

    Small

    Keywords

    click chemistry; drug delivery; magnetic materials; magnetic resonance; imaging; IN-VIVO; MAGNETIC NANOPARTICLES; CLICK CHEMISTRY; CELLS; DELIVERY; PROBE; VITRO; Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &; Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter

    Abstract

    A biocompatible, multimodal, and theranostic functional iron oxide nanoparticle is synthesized using a novel water-based method and exerts excellent properties for targeted cancer therapy, and optical and magnetic resonance imaging. For the first time, a facile, modified solvent diffusion method is used for the co-encapsulation of both. an anticancer drug and near-infrared dyes. The resulting folate-derivatized theranostics nanoparticles could allow for targeted optical/magnetic resonance imaging and targeted killing of folate-expressing cancer cells.

    Journal Title

    Small

    Volume

    5

    Issue/Number

    16

    Publication Date

    1-1-2009

    Document Type

    Article

    Language

    English

    First Page

    1862

    Last Page

    1868

    WOS Identifier

    WOS:000269227800010

    ISSN

    1613-6810

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