Abbreviated Journal Title
J. Bacteriol.
Keywords
DIMYCOCEROSYL PHTHIOCEROL SYNTHESIS; BACILLUS-CALMETTE-GUERIN; MULTIFUNCTIONAL ENZYME; GENE-CLUSTER; BOVIS BCG; SYNTHASE; FORTUITUM; FAMILY; DISRUPTION; COMPLEX; Microbiology
Abstract
We show that the disruption of one of the mycocerosic acid synthase (mas)-like genes, msl5 (pks8 plus pks17) in Mycobacterium tuberculosis H37Rv generates a mutant incapable of producing monomethyl branched unsaturated C-16 to C-20 fatty acids that are minor constituents of acyltrehaloses and sulfolipids. The msl5 mutation did not cause any significant change in the acyl lipid composition and also did not affect growth in culture, in mouse alveolar macrophage cell line MH-S, or in the murine lung.
Journal Title
Journal of Bacteriology
Volume
185
Issue/Number
15
Publication Date
1-1-2003
Document Type
Article
Language
English
First Page
4620
Last Page
4625
WOS Identifier
ISSN
0021-9193
Recommended Citation
Dubey, Vinod S.; Sirakova, Tatiana D.; Cynamon, Michael H.; and Kolattukudy, Pappachan E., "Biochemical function of msl5 (pks8 plus pks17) in Mycobacterium tuberculosis H37Rv: Biosynthesis of monomethyl branched unsaturated fatty acids" (2003). Faculty Bibliography 2000s. 3722.
https://stars.library.ucf.edu/facultybib2000/3722