Neural membrane field effects in a cytoskeleton corral: Microdomain regulation of impulse propagation

    Authors

    R. Wallace

    Comments

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    Abbreviated Journal Title

    Int. J. Quantum Chem.

    Keywords

    membranes; cytoskeleton; conduction failure; microdomains; rafts; ACTION-POTENTIAL PROPAGATION; SHAKER POTASSIUM CHANNEL; CELL-MEMBRANES; TRANSMEMBRANE SEGMENTS; LATERAL DIFFUSION; CONDUCTION BLOCK; HOP; DIFFUSION; K+ CHANNEL; MODEL; AXON; Chemistry, Physical; Mathematics, Interdisciplinary Applications; Physics, Atomic, Molecular & Chemical

    Abstract

    This article proposes that electrostatic interaction between transiently polarized neural-membrane ethenes and charged residues of an unfolded ion-channel protein regulate channel closing and electrical signaling in neurons. Field effects are confined by a cytoskeleton corral that gates movement of membrane lipids from one corralled region to another. Cytoskeleton gating permits stepwise changes in the concentration of unsaturated lipids and thereby modulates ion-channel activity. The system is hypothesized to operate at axonal branch points where impulse conduction has a low safety factor. Throughout the discussion the A-current delayed-rectifier potassium channel is used as an example. Implications of the model for molecular networks are briefly discussed. (C) 2004 Wiley Periodicals, Inc.

    Journal Title

    International Journal of Quantum Chemistry

    Volume

    100

    Issue/Number

    6

    Publication Date

    1-1-2004

    Document Type

    Article; Proceedings Paper

    Language

    English

    First Page

    1038

    Last Page

    1046

    WOS Identifier

    WOS:000224788600024

    ISSN

    0020-7608

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