Title

Neural membrane field effects in a cytoskeleton corral: Microdomain regulation of impulse propagation

Authors

Authors

R. Wallace

Comments

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Abbreviated Journal Title

Int. J. Quantum Chem.

Keywords

membranes; cytoskeleton; conduction failure; microdomains; rafts; ACTION-POTENTIAL PROPAGATION; SHAKER POTASSIUM CHANNEL; CELL-MEMBRANES; TRANSMEMBRANE SEGMENTS; LATERAL DIFFUSION; CONDUCTION BLOCK; HOP; DIFFUSION; K+ CHANNEL; MODEL; AXON; Chemistry, Physical; Mathematics, Interdisciplinary Applications; Physics, Atomic, Molecular & Chemical

Abstract

This article proposes that electrostatic interaction between transiently polarized neural-membrane ethenes and charged residues of an unfolded ion-channel protein regulate channel closing and electrical signaling in neurons. Field effects are confined by a cytoskeleton corral that gates movement of membrane lipids from one corralled region to another. Cytoskeleton gating permits stepwise changes in the concentration of unsaturated lipids and thereby modulates ion-channel activity. The system is hypothesized to operate at axonal branch points where impulse conduction has a low safety factor. Throughout the discussion the A-current delayed-rectifier potassium channel is used as an example. Implications of the model for molecular networks are briefly discussed. (C) 2004 Wiley Periodicals, Inc.

Journal Title

International Journal of Quantum Chemistry

Volume

100

Issue/Number

6

Publication Date

1-1-2004

Document Type

Article; Proceedings Paper

Language

English

First Page

1038

Last Page

1046

WOS Identifier

WOS:000224788600024

ISSN

0020-7608

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