Antimicrobial peptide microbicides targeting HIV

    Authors

    A. M. Cole

    Comments

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    Abbreviated Journal Title

    Protein Pept. Lett.

    Keywords

    antimicrobial; peptide; defensin; HIV-1; cathelicidin; human; minidefensin; STD; HUMAN-IMMUNODEFICIENCY-VIRUS; RHESUS-MACAQUE LEUKOCYTES; HOST-DEFENSE; ALPHA-DEFENSINS; INNATE IMMUNITY; BETA-DEFENSIN; BACTERICIDAL ACTIVITY; CHASSALIA-PARVIFOLIA; TOPICAL MICROBICIDES; ANTI-HIV-1 ACTIVITY; Biochemistry & Molecular Biology

    Abstract

    Cationic antimicrobial peptides and proteins are among the earliest molecular effectors of the innate arm of immunity in humans and other vertebrates. This review, inspired by recent emphasis on the development of topical preventatives for sexually transmitted infections, describes antimicrobial peptides and proteins in the context of microbicide design and development. Particular emphasis is placed on the defensin family of peptides.

    Journal Title

    Protein and Peptide Letters

    Volume

    12

    Issue/Number

    1

    Publication Date

    1-1-2005

    Document Type

    Article

    Language

    English

    First Page

    41

    Last Page

    47

    WOS Identifier

    WOS:000226057400008

    ISSN

    0929-8665

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