Decreased clearance of Pseudomonas aeruginosa from airways of mice deficient in lysozyme M

    Authors

    A. M. Cole; D. R. Thapa; V. Gabayan; H. I. Liao; L. Liu;T. Ganz

    Comments

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    Abbreviated Journal Title

    J. Leukoc. Biol.

    Keywords

    knockout; bacteria; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; CATIONIC POLYPEPTIDES; MURAMIDASE; PEPTIDES; Cell Biology; Hematology; Immunology

    Abstract

    Lysozyme is a ubiquitous and abundant, cationic, antimicrobial polypeptide of leukocytes and epithelia, but its biological function in host defense is largely unexplored. To ascertain the role of lysozyme during bacterial infection of murine airways, we exposed the airways of lysozyme M-deficient (lys M-/-) mice to the pulmonary pathogen Pseudomonas aeruginosa and examined the host's response to infection. Despite partial compensation as a result of the appearance of lysozyme P in the infected airways of lys M-/- mice, these lys M-/- mice showed decreased clearance of P. aeruginosa compared with their lys M+/- or lys M+/+ littermates. Lysozyme contributes to optimal clearance of P. aeruginosa from the murine airways.

    Journal Title

    Journal of Leukocyte Biology

    Volume

    78

    Issue/Number

    5

    Publication Date

    1-1-2005

    Document Type

    Article

    Language

    English

    First Page

    1081

    Last Page

    1085

    WOS Identifier

    WOS:000233095200006

    ISSN

    0741-5400

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