Title

Fabrication of ultrathin polyelectrolyte fibers and their controlled release properties

Authors

Authors

A. Chunder; S. Sarkar; Y. B. Yu;L. Zhai

Comments

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Abbreviated Journal Title

Colloid Surf. B-Biointerfaces

Keywords

electrospun; weak polyelectrolytes; cationic molecules; controlled; release; CONTROLLED DRUG-RELEASE; SUSTAINED-RELEASE; N-ISOPROPYLACRYLAMIDE; POLY(ACRYLIC ACID); MULTILAYER FILMS; DELIVERY-SYSTEM; THIN-FILMS; POLYMER; NANOPARTICLES; NANOFIBERS; Biophysics; Chemistry, Physical; Materials Science, Biomaterials

Abstract

Ultrathin fibers comprising 2-weak polyelectrolytes, poly(acrylic acid) (PAA) and poly(allylamine hydrochloride) (PAH) were fabricated using the electrospinning technique. Methylene blue (MB) was used as a model drug to evaluate the potential application of the fibers for drug delivery. The release of MB was controlled in a nonbuffered medium by changing the pH of the solution. The sustained release of MB in a phosphate buffered saline (PBS) solution was achieved by constructing perfluorosilane networks on the fiber surfaces as capping layers. Temperature controlled release of MB was obtained by depositing temperature sensitive PAA/poly(N-isopropylacrylamide) (PNIPAAM) multilayers onto the fiber surfaces. The controlled release of drugs from electrospun fibers have potential applications as drug carriers in biomedical science. (C) 2007 Elsevier B.V. All rights reserved.

Journal Title

Colloids and Surfaces B-Biointerfaces

Volume

58

Issue/Number

2

Publication Date

1-1-2007

Document Type

Article

Language

English

First Page

172

Last Page

179

WOS Identifier

WOS:000248038400012

ISSN

0927-7765

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