Fabrication of ultrathin polyelectrolyte fibers and their controlled release properties

    Authors

    A. Chunder; S. Sarkar; Y. B. Yu;L. Zhai

    Comments

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    Abbreviated Journal Title

    Colloid Surf. B-Biointerfaces

    Keywords

    electrospun; weak polyelectrolytes; cationic molecules; controlled; release; CONTROLLED DRUG-RELEASE; SUSTAINED-RELEASE; N-ISOPROPYLACRYLAMIDE; POLY(ACRYLIC ACID); MULTILAYER FILMS; DELIVERY-SYSTEM; THIN-FILMS; POLYMER; NANOPARTICLES; NANOFIBERS; Biophysics; Chemistry, Physical; Materials Science, Biomaterials

    Abstract

    Ultrathin fibers comprising 2-weak polyelectrolytes, poly(acrylic acid) (PAA) and poly(allylamine hydrochloride) (PAH) were fabricated using the electrospinning technique. Methylene blue (MB) was used as a model drug to evaluate the potential application of the fibers for drug delivery. The release of MB was controlled in a nonbuffered medium by changing the pH of the solution. The sustained release of MB in a phosphate buffered saline (PBS) solution was achieved by constructing perfluorosilane networks on the fiber surfaces as capping layers. Temperature controlled release of MB was obtained by depositing temperature sensitive PAA/poly(N-isopropylacrylamide) (PNIPAAM) multilayers onto the fiber surfaces. The controlled release of drugs from electrospun fibers have potential applications as drug carriers in biomedical science. (C) 2007 Elsevier B.V. All rights reserved.

    Journal Title

    Colloids and Surfaces B-Biointerfaces

    Volume

    58

    Issue/Number

    2

    Publication Date

    1-1-2007

    Document Type

    Article

    Language

    English

    First Page

    172

    Last Page

    179

    WOS Identifier

    WOS:000248038400012

    ISSN

    0927-7765

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