Fabrication of ultrathin polyelectrolyte fibers and their controlled release properties
Abbreviated Journal Title
Colloid Surf. B-Biointerfaces
electrospun; weak polyelectrolytes; cationic molecules; controlled; release; CONTROLLED DRUG-RELEASE; SUSTAINED-RELEASE; N-ISOPROPYLACRYLAMIDE; POLY(ACRYLIC ACID); MULTILAYER FILMS; DELIVERY-SYSTEM; THIN-FILMS; POLYMER; NANOPARTICLES; NANOFIBERS; Biophysics; Chemistry, Physical; Materials Science, Biomaterials
Ultrathin fibers comprising 2-weak polyelectrolytes, poly(acrylic acid) (PAA) and poly(allylamine hydrochloride) (PAH) were fabricated using the electrospinning technique. Methylene blue (MB) was used as a model drug to evaluate the potential application of the fibers for drug delivery. The release of MB was controlled in a nonbuffered medium by changing the pH of the solution. The sustained release of MB in a phosphate buffered saline (PBS) solution was achieved by constructing perfluorosilane networks on the fiber surfaces as capping layers. Temperature controlled release of MB was obtained by depositing temperature sensitive PAA/poly(N-isopropylacrylamide) (PNIPAAM) multilayers onto the fiber surfaces. The controlled release of drugs from electrospun fibers have potential applications as drug carriers in biomedical science. (C) 2007 Elsevier B.V. All rights reserved.
Colloids and Surfaces B-Biointerfaces
"Fabrication of ultrathin polyelectrolyte fibers and their controlled release properties" (2007). Faculty Bibliography 2000s. 6961.