One-step, nanoparticle-mediated bacterial detection with magnetic relaxation

    Authors

    C. Kaittanis; S. A. Naser;J. M. Perez

    Comments

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    Abbreviated Journal Title

    Nano Lett.

    Keywords

    AVIUM SUBSPECIES PARATUBERCULOSIS; CROHNS-DISEASE; MYCOBACTERIUM-PARATUBERCULOSIS; IDENTIFICATION; PROBES; Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &; Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter

    Abstract

    Acknowledging the need for the development of fast and sensitive bacterial detection methods, we functionalized superparamagnetic iron oxide nanoparticles to identify Mycobacterium avium spp. paratuberculosis (MAP), through magnetic relaxation. Our results indicate that the MAP nanoprobes (1) bind specifically to MAP, (2) can quantify the bacterial target quickly in milk and blood with high sensitivity, and (3) are not susceptible to interferences caused by other bacteria. The use of the described magnetic nanosensors in the identification and quantification of bacteria in clinical and environmental samples is anticipated.

    Journal Title

    Nano Letters

    Volume

    7

    Issue/Number

    2

    Publication Date

    1-1-2007

    Document Type

    Article

    Language

    English

    First Page

    380

    Last Page

    383

    WOS Identifier

    WOS:000244206500029

    ISSN

    1530-6984

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