Abbreviated Journal Title
J. Chem. Phys.
Keywords
MONTE-CARLO-SIMULATION; SOLID-STATE NANOPORE; POLYMER TRANSLOCATION; POLYNUCLEOTIDE MOLECULES; DNA TRANSLOCATION; MEMBRANE CHANNEL; DYNAMICS; DRIVEN; PROTEINS; DISCRIMINATION; Physics, Atomic, Molecular & Chemical
Abstract
The authors investigate the translocation dynamics of heteropolymers driven through a nanopore using a constant temperature Langevin thermostat. Specifically, they consider heteropolymers consisting of two types of monomers labeled A and B, which are distinguished by the magnitude of the driving force that they experience inside the pore. From a series of studies on polymers with sequences A(m)B(n) the authors identify both universal as well as specific sequence properties of the translocating chains. They find that the scaling of the average translocation time as a function of the chain length N remains unaffected by the heterogeneity, while the residence time of each bead is a strong function of the sequence for short repeat units. They further discover that for a symmetric heteropolymer A(n)B(n) of fixed length, the pattern exhibited by the residence times of the individual monomers has striking similarity with a double slit interference pattern where the total number of repeat units N/2n controls the number of interference fringes. These results are relevant for designing nanopore based sequencing techniques.
Journal Title
Journal of Chemical Physics
Volume
126
Issue/Number
14
Publication Date
1-1-2007
Document Type
Article
DOI Link
Language
English
First Page
7
WOS Identifier
ISSN
0021-9606
Recommended Citation
Luo, Kaifu; Ala-Nissila, Tapio; Ying, See-Chen; and Bhattacharya, Aniket, "Heteropolymer translocation through nanopores" (2007). Faculty Bibliography 2000s. 7386.
https://stars.library.ucf.edu/facultybib2000/7386
Comments
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