Title

Nanoscale mechanics of solid-supported multilayered lipid films by force measurement

Authors

Authors

W. Ngwa; K. Chen; A. Sahgal; E. V. Stepanov;W. Luo

Comments

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Abbreviated Journal Title

Thin Solid Films

Keywords

nanomechanics; atomic force microscopy (AFM); bilayer membrane; structure and elastic properties; Young's modulus; spin-coating; solution spreading; lipid films; ALIGNED PHOSPHOLIPID-MEMBRANES; ELASTIC PROPERTIES; NANOMECHANICAL; PROPERTIES; POLYMER-FILMS; X-RAY; MICROSCOPY; BILAYERS; SURFACE; VESICLES; REFLECTIVITY; Materials Science, Multidisciplinary; Materials Science, Coatings &; Films; Physics, Applied; Physics, Condensed Matter

Abstract

Using atomic force microscopy and molecular force probe, we have studied the structure and nanomechanical response to nano-indentation of multilayered films of dioleoylphosphatidylcholine films prepared by solution spreading, spin-coating, and capillary methods. The influence of the film thickness on the apparent elastic (Young's) modulus is investigated. Young's moduli of samples prepared by the different methods were found to be similar for sufficiently thick films. An ostensible influence of substrate coupling on the apparent Young's modulus is observed for thinner lipid films. The results are discussed in comparison with previously reported estimates for supported lipid bilayers (membranes) and cells. (C) 2008 Elsevier B.V. All rights reserved.

Journal Title

Thin Solid Films

Volume

516

Issue/Number

15

Publication Date

1-1-2008

Document Type

Article

Language

English

First Page

5039

Last Page

5045

WOS Identifier

WOS:000256509100061

ISSN

0040-6090

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