Nanoscale mechanics of solid-supported multilayered lipid films by force measurement

    Authors

    W. Ngwa; K. Chen; A. Sahgal; E. V. Stepanov;W. Luo

    Comments

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    Abbreviated Journal Title

    Thin Solid Films

    Keywords

    nanomechanics; atomic force microscopy (AFM); bilayer membrane; structure and elastic properties; Young's modulus; spin-coating; solution spreading; lipid films; ALIGNED PHOSPHOLIPID-MEMBRANES; ELASTIC PROPERTIES; NANOMECHANICAL; PROPERTIES; POLYMER-FILMS; X-RAY; MICROSCOPY; BILAYERS; SURFACE; VESICLES; REFLECTIVITY; Materials Science, Multidisciplinary; Materials Science, Coatings &; Films; Physics, Applied; Physics, Condensed Matter

    Abstract

    Using atomic force microscopy and molecular force probe, we have studied the structure and nanomechanical response to nano-indentation of multilayered films of dioleoylphosphatidylcholine films prepared by solution spreading, spin-coating, and capillary methods. The influence of the film thickness on the apparent elastic (Young's) modulus is investigated. Young's moduli of samples prepared by the different methods were found to be similar for sufficiently thick films. An ostensible influence of substrate coupling on the apparent Young's modulus is observed for thinner lipid films. The results are discussed in comparison with previously reported estimates for supported lipid bilayers (membranes) and cells. (C) 2008 Elsevier B.V. All rights reserved.

    Journal Title

    Thin Solid Films

    Volume

    516

    Issue/Number

    15

    Publication Date

    1-1-2008

    Document Type

    Article

    Language

    English

    First Page

    5039

    Last Page

    5045

    WOS Identifier

    WOS:000256509100061

    ISSN

    0040-6090

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