Integration of functional myotubes with a Bio-MEMS device for non-invasive interrogation

    Authors

    K. Wilson; P. Molnar;J. Hickman

    Comments

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    Abbreviated Journal Title

    Lab Chip

    Keywords

    SERUM-FREE MEDIUM; DEFINED SYSTEM; MUSCLE; CULTURE; Biochemical Research Methods; Chemistry, Multidisciplinary; Nanoscience; & Nanotechnology

    Abstract

    We have developed a biological micro-electromechanical system (Bio-MEMS) device consisting of surface-modified microfabricated silicon cantilevers and an AFM detection apparatus for the study of cultured myotubes. With this system we are able to selectively stimulate the myotubes as well as report on a variety of physiological properties of the myotubes in real time and in a high-throughput manner. This system will serve as the foundation for future work integrating multiple tissue types for the creation of Bio-MEMS analogues of complex tissues and biological circuits.

    Journal Title

    Lab on a Chip

    Volume

    7

    Issue/Number

    7

    Publication Date

    1-1-2007

    Document Type

    Article

    Language

    English

    First Page

    920

    Last Page

    922

    WOS Identifier

    WOS:000247543700028

    ISSN

    1473-0197

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