Test for the consistency of noninferiority from multiple clinical trials

    Authors

    X. Yan; M. C. Wang;X. G. Su

    Comments

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    Abbreviated Journal Title

    J. Biopharm. Stat.

    Keywords

    lower confidence bound; noninferiority; power function; simultaneous; inference; test size; Pharmacology & Pharmacy; Statistics & Probability

    Abstract

    A testing procedure is proposed to assess the consistency of noninferiority from a collection of trials based on simultaneous t lower confidence bounds or Scheffe's lower confidence bounds. Methods for simultaneous inferences on pairwise or many-to-one comparisons among multiple noninferiority trials are also discussed. To avoid bias due to subjective trial exclusion a tuning parameter k is embedded into the testing procedure to provide flexibility to quantify the "consistency of noninferiority" when the total number of trials is large. The size and power of the proposed test are discussed. The method is illustrated using simulations and real data analysis.

    Journal Title

    Journal of Biopharmaceutical Statistics

    Volume

    17

    Issue/Number

    2

    Publication Date

    1-1-2007

    Document Type

    Article

    Language

    English

    First Page

    265

    Last Page

    278

    WOS Identifier

    WOS:000244942300007

    ISSN

    1054-3406

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