Title

Test for the consistency of noninferiority from multiple clinical trials

Authors

Authors

X. Yan; M. C. Wang;X. G. Su

Comments

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Abbreviated Journal Title

J. Biopharm. Stat.

Keywords

lower confidence bound; noninferiority; power function; simultaneous; inference; test size; Pharmacology & Pharmacy; Statistics & Probability

Abstract

A testing procedure is proposed to assess the consistency of noninferiority from a collection of trials based on simultaneous t lower confidence bounds or Scheffe's lower confidence bounds. Methods for simultaneous inferences on pairwise or many-to-one comparisons among multiple noninferiority trials are also discussed. To avoid bias due to subjective trial exclusion a tuning parameter k is embedded into the testing procedure to provide flexibility to quantify the "consistency of noninferiority" when the total number of trials is large. The size and power of the proposed test are discussed. The method is illustrated using simulations and real data analysis.

Journal Title

Journal of Biopharmaceutical Statistics

Volume

17

Issue/Number

2

Publication Date

1-1-2007

Document Type

Article

Language

English

First Page

265

Last Page

278

WOS Identifier

WOS:000244942300007

ISSN

1054-3406

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