A computational model of membrane lipid electronic properties in relation to neural signaling
Abbreviated Journal Title
Biosystems
Keywords
hydrophobic mismatch; neural membrane; lipids; computational modeling; molecular computing; spectroscopy; SENSITIVE ION CHANNELS; HUMAN BRAIN EVOLUTION; PROTEIN INTERACTIONS; HYDROPHOBIC MISMATCH; QUANTUM COMPUTATION; CELL-MEMBRANES; PHOSPHOLIPIDS; ORGANIZATION; CHOLESTEROL; CONDUCTION; Biology; Mathematical & Computational Biology
Abstract
We present a computational model of a transiently-organized neural membrane molecular system with possible information-processing capacity. The model examines field-induced dipole and quadrupole moments and polarizability in monomeric, dimeric. and trimeric ethenes. Polarization of the ethenes is strongly indicated. This result is interpreted as a significant electronic feature of a molecular computing system based on organization of membrane lipids into a transient (similar to 10(-4) s) crystalline state due to lipid-protein hydrophobic mismatch at the membrane-ion-channel interface. Predictive implications of the model's electronic features are briefly discussed. (C) 2001 Elsevier Science Ireland Ltd. All rights: reserved.
Journal Title
Biosystems
Volume
59
Issue/Number
1
Publication Date
1-1-2001
Document Type
Article
Language
English
First Page
27
Last Page
34
WOS Identifier
ISSN
0303-2647
Recommended Citation
"A computational model of membrane lipid electronic properties in relation to neural signaling" (2001). Faculty Bibliography 2000s. 8160.
https://stars.library.ucf.edu/facultybib2000/8160