Gold-Speckled Multimodal Nanoparticles for Noninvasive Bioimaging

    Authors

    P. Sharma; S. C. Brown; N. Bengtsson; Q. Z. Zhang; G. A. Walter; S. R. Grobmyer; S. Santra; H. B. Jiang; E. W. Scott;B. M. Moudgil

    Comments

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    Abbreviated Journal Title

    Chem. Mat.

    Keywords

    OPTICAL CONTRAST AGENT; OPTOACOUSTIC IMAGING-SYSTEM; BRAINS IN-VIVO; PHOTOACOUSTIC TOMOGRAPHY; BIOLOGICAL TISSUES; MRI; NANOSHELLS; SENSITIVITY; FLUORESCENT; RESONANCE; Chemistry, Physical; Materials Science, Multidisciplinary

    Abstract

    In this report the synthesis, characterization, and financial evaluation of a multimodal nanoparticulate Contrast agent for noninvasive imaging through both magnetic resonance imaging, (MRI) and photoacoustic tomography (PAT) is presented. The nanoparticles described herein enable high resolution and highly sensitive three-dimensional diagnostic imaging through the synergistic coupling of MRI and PAT capabilities. Gadoliniurn (15d)-doped gold-speckled silica (GSS) nanoparticles. ranging from 50 to 200 Jim. have been prepared in a simple one-pot synthesis using nonionic microemulsions. The photoacoustic signal is generated from a nonuniform, discontinuous gold nanodomains speckled across the silica surface, whereas the MR contrast is provided through Gd incorporated in the silica matrix. The presence of a discontinuous speckled Surface, as opposed to a Continuous gold shell, allows sufficient bulk water exchange with the Gd ions to generate a strong MR contrast. The dual imaging capabilities of the particles have been demonstrated through in silicio and in vitro methods. The described particles also have the capacity for therapeutic

    Journal Title

    Chemistry of Materials

    Volume

    20

    Issue/Number

    19

    Publication Date

    1-1-2008

    Document Type

    Article

    Language

    English

    First Page

    6087

    Last Page

    6094

    WOS Identifier

    WOS:000259871500021

    ISSN

    0897-4756

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