STAT3 as a target for inducing apoptosis in solid and hematological tumors

    Authors

    K. A. Z. Siddiquee;J. Turkson

    Comments

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    Abbreviated Journal Title

    Cell Res.

    Keywords

    STAT3; DNA-binding; apoptosis; small-molecule inhibitors; cell growth; human tumors; BREAST-CANCER CELLS; HUMAN PANCREATIC-CANCER; JANUS KINASE/SIGNAL; TRANSDUCER; CONSTITUTIVE SIGNAL TRANSDUCER; ANAPLASTIC LYMPHOMA KINASE; RECEPTOR TYROSINE KINASES; ENDOTHELIAL GROWTH-FACTOR; POTENT; ANTITUMOR-ACTIVITY; NON-HODGKINS-LYMPHOMA; DNA-BINDING ACTIVITY; Cell Biology

    Abstract

    Studies in the past few years have provided compelling evidence for the critical role of aberrant Signal Transducer and Activator of Transcription 3 (STAT3) in malignant transformation and tumorigenesis. Thus, it is now generally accepted that STAT3 is one of the critical players in human cancer formation and represents a valid target for novel anticancer drug design. This review focuses on aberrant STAT3 and its role in promoting tumor cell survival and supporting the malignant phenotype. A brief evaluation of the current strategies targeting STAT3 for the development of novel anticancer agents against human tumors harboring constitutively active STAT3 will also be presented.

    Journal Title

    Cell Research

    Volume

    18

    Issue/Number

    2

    Publication Date

    1-1-2008

    Document Type

    Review

    Language

    English

    First Page

    254

    Last Page

    267

    WOS Identifier

    WOS:000254024700007

    ISSN

    1001-0602

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