Title

STAT3 as a target for inducing apoptosis in solid and hematological tumors

Authors

Authors

K. A. Z. Siddiquee;J. Turkson

Comments

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Abbreviated Journal Title

Cell Res.

Keywords

STAT3; DNA-binding; apoptosis; small-molecule inhibitors; cell growth; human tumors; BREAST-CANCER CELLS; HUMAN PANCREATIC-CANCER; JANUS KINASE/SIGNAL; TRANSDUCER; CONSTITUTIVE SIGNAL TRANSDUCER; ANAPLASTIC LYMPHOMA KINASE; RECEPTOR TYROSINE KINASES; ENDOTHELIAL GROWTH-FACTOR; POTENT; ANTITUMOR-ACTIVITY; NON-HODGKINS-LYMPHOMA; DNA-BINDING ACTIVITY; Cell Biology

Abstract

Studies in the past few years have provided compelling evidence for the critical role of aberrant Signal Transducer and Activator of Transcription 3 (STAT3) in malignant transformation and tumorigenesis. Thus, it is now generally accepted that STAT3 is one of the critical players in human cancer formation and represents a valid target for novel anticancer drug design. This review focuses on aberrant STAT3 and its role in promoting tumor cell survival and supporting the malignant phenotype. A brief evaluation of the current strategies targeting STAT3 for the development of novel anticancer agents against human tumors harboring constitutively active STAT3 will also be presented.

Journal Title

Cell Research

Volume

18

Issue/Number

2

Publication Date

1-1-2008

Document Type

Review

Language

English

First Page

254

Last Page

267

WOS Identifier

WOS:000254024700007

ISSN

1001-0602

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