Title
Evaluation of p16(INK4a) Immunohistochemical Reactivity in Endocervical Glandular Neoplasia
Abbreviated Journal Title
J. Low. Genit. Tract. Dis.
Keywords
endocervical adenocarcinoma; p16(INK4a); immunohistochemistry; SQUAMOUS-CELL CARCINOMA; UTERINE CERVIX; ADENOCARCINOMA; ENDOMETRIAL; EXPRESSION; DIAGNOSIS; MARKER; CANCER; HPV; OVEREXPRESSION; Obstetrics & Gynecology
Abstract
Objective. To determine the expression of p16(INK4a) by immunohistochemistry in endocervical neoplasms. Methods. Forty-nine cases of endocervical glandular neoplasia were identified by record review. On histopathologic review of the original and new slides, 16 cases were identified as endocervical adenocarcinoma in situ (AIS), 31 were identified as invasive adenocarcinoma, and 2 had no remaining tumor identified. A representative paraffin block was selected from each case with tumor and sections cut from each block. One section from each case was stained with hematoxylin and eosin, 1 was processed for immunohistochemical study for p16(INK4a), and 1 was a negative control. The nuclear immunoreactivity was graded positive, indeterminate, or negative. Results. Cases were classified AIS, adenocarcinoma, or no tumor. Of 16 cases of AIS, 15 (93.01%) cases were immunoreactive to p16(INK4a); 1 case was negative. All cases of invasive adenocarcinoma, 31 of 31 cases (100%), were immunoreactive to p16(INK4a). Conclusions. p16(INK4a) reactivity can be used to help identify and assess in situ and invasive endocervical glandular neoplasms.
Journal Title
Journal of Lower Genital Tract Disease
Volume
15
Issue/Number
1
Publication Date
1-1-2011
Document Type
Article
Language
English
First Page
1
Last Page
5
WOS Identifier
ISSN
1089-2591
Recommended Citation
"Evaluation of p16(INK4a) Immunohistochemical Reactivity in Endocervical Glandular Neoplasia" (2011). Faculty Bibliography 2010s. 1681.
https://stars.library.ucf.edu/facultybib2010/1681
Comments
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