Intraperitoneal photodynamic therapy mediated by a fullerene in a mouse model of abdominal dissemination of colon adenocarcinoma

    Authors

    P. Mroz; Y. M. Xia; D. Asanuma; A. Konopko; T. Zhiyentayev; Y. Y. Huang; S. K. Sharma; T. H. Dai; U. J. Khan; T. Wharton;M. R. Hamblin

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    Abbreviated Journal Title

    Nanomed.-Nanotechnol. Biol. Med.

    Keywords

    Photodynamic therapy; Functionalized fullerene; Disseminated abdominal; cancer; Micellar formulation; Hydroxyl radicals; PHASE-II TRIAL; PERITONEAL CARCINOMATOSIS; FUNCTIONALIZED FULLERENES; OXYGEN; C-60; KERATINOCYTES; SENSITIZERS; GENERATION; MECHANISM; MICELLES; Nanoscience & Nanotechnology; Medicine, Research & Experimental

    Abstract

    Functionalized fullerenes represent a new class of photosensitizer (PS) that is being investigated for photodynamic therapy (PDT) of various diseases, including cancer. We tested the hypothesis that fullerenes could be used to mediate PDT of intraperitoneal (IP) carcinomatosis in a mouse model. In humans this form of cancer responds poorly to standard treatment and manifests as a thin covering of tumor nodules on intestines and on other abdominal organs. We used a colon adenocarcinoma cell line (CT26) stably expressing luciferase to allow monitoring of IP tumor burden in BALB/c mice by noninvasive real-time optical imaging using a sensitive low-light camera. IP injection of a preparation of N-methylpyrrolidinium-fullerene formulated in Cremophor-EL micelles, followed by white-light illumination delivered through the peritoneal wall (after creation of a skin flap), produced a statistically significant reduction in bioluminescence and a survival advantage in mice. From the Clinical Editor: This team of investigators report on functionalized fullerenes, to be used as photosensitizer for photodynamic therapy and demonstrate the efficacy of this method in an intraperitoneal carcinomatosis mouse model. (C) 2011 Elsevier Inc. All rights reserved.

    Journal Title

    Nanomedicine-Nanotechnology Biology and Medicine

    Volume

    7

    Issue/Number

    6

    Publication Date

    1-1-2011

    Document Type

    Article

    Language

    English

    First Page

    965

    Last Page

    974

    WOS Identifier

    WOS:000297699900033

    ISSN

    1549-9634

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