Clinical Manifestations and Treatment of Drug-induced Hepatotoxicity

    Authors

    C. M. Giordano;X. B. Zervos

    Comments

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    Abbreviated Journal Title

    Clin. Liver Dis.

    Keywords

    Drug-induced liver injury; Drug-induced cholestasis; Drug-induced; hepatocellular injury; Management of drug-induced liver injury; INDUCED LIVER-INJURY; LYMPHOCYTE-TRANSFORMATION TEST; UNITED-STATES; CAUSALITY ASSESSMENT; DIAGNOSTIC SCALE; HYPERSENSITIVITY; ACETYLCYSTEINE; DISORDERS; OUTCOMES; FAILURE; Gastroenterology & Hepatology

    Abstract

    With an increase of prescription medication and herbal supplement use, drug-induced liver injury (DILI) has become an increasingly important entity. Because DILI is a usually readily treatable condition, it is essential for providers to reach a diagnosis in a timely fashion. Unfortunately, varied clinical presentations, difficulties in establishing causality, and lack of a gold standard diagnostic criterion may make early diagnosis difficult. This article seeks to define commonly used terminology, describe common clinical presentations of DILI, provide an overview of current diagnostic criteria, and provide management guidelines.

    Journal Title

    Clinics in Liver Disease

    Volume

    17

    Issue/Number

    4

    Publication Date

    1-1-2013

    Document Type

    Article

    Language

    English

    First Page

    565

    Last Page

    +

    WOS Identifier

    WOS:000326659500006

    ISSN

    1089-3261

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