Interplay between Velocity and Travel Distance of Kinesin-based Transport in the Presence of Tau

    Authors

    J. Xu; S. J. King; M. Lapierre-Landry;B. Nemec

    Comments

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    Abbreviated Journal Title

    Biophys. J.

    Keywords

    TUG-OF-WAR; MICROTUBULE SURFACE; MOTOR; DYNEIN; PROCESSIVITY; PROTEINS; LATTICE; Biophysics

    Abstract

    Although the disease-relevant microtubule-associated protein tau is known to severely inhibit kinesin-based transport in vitro, the potential mechanisms for reversing this detrimental effect to maintain healthy transport in cells remain unknown. Here we report the unambiguous upregulation of multiple-kinesin travel distance despite the presence of tau, via decreased single-kinesin velocity. Interestingly, the presence of tau also modestly reduced cargo velocity in multiple-kinesin transport, and our stochastic simulations indicate that the tau-mediated reduction in single-kinesin travel underlies this observation. Taken together, our observations highlight a nontrivial interplay between velocity and travel distance for kinesin transport, and suggest that single-kinesin velocity is a promising experimental handle for tuning the effect of tau on multiple-kinesin travel distance.

    Journal Title

    Biophysical Journal

    Volume

    105

    Issue/Number

    10

    Publication Date

    1-1-2013

    Document Type

    Article

    Language

    English

    First Page

    L23

    Last Page

    L25

    WOS Identifier

    WOS:000327285100001

    ISSN

    0006-3495

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