Title

Nanoceria and Thioredoxin Regulate a Common Antioxidative Gene Network in tubby Mice

Authors

Authors

X. Cai; J. J. Yodoi; S. Seal;J. F. McGinnis

Comments

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Abbreviated Journal Title

Adv.Exp.Med.Biol.

Keywords

Tubby mouse; Nanoceria; Thioredoxin; Oxidative stress and antioxidant; defense; PCR array; SOD1-DEFICIENT MICE; DEGENERATION; CELLS; NUCLEOREDOXIN; DYSFUNCTION; MECHANISM; STRESS; Biology; Medicine, Research & Experimental; Ophthalmology

Abstract

Oxidative stress is a node common to the causes and effects of various ocular diseases. We have shown that thioredoxin has neuroprotective effects on tubby photoreceptors. We also demonstrated that nanoceria (cerium oxide nanoparticles), which are direct antioxidants, have long-term effects on prevention of retinal degeneration in tubby mice. Here, using commercially available PCR array plates, we surveyed the regulation in expression of 89 oxidative stress-associated genes in the eyes of P12 tubby mice which are either intravitreally injected with nanoceria or in which the Trx gene is overexpressed. Our data demonstrate that nanoceria and Trx regulate the same group of genes associated with antioxidative stress and antioxidant defense.

Journal Title

Retinal Degenerative Diseases: Mechanisms and Experimental Therapy

Volume

801

Publication Date

1-1-2014

Document Type

Article

Language

English

First Page

829

Last Page

836

WOS Identifier

WOS:000350418200105

ISSN

0065-2598; 978-1-4614-3209-8; 978-1-4614-3208-1

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