Nanoceria and Thioredoxin Regulate a Common Antioxidative Gene Network in tubby Mice

    Authors

    X. Cai; J. J. Yodoi; S. Seal;J. F. McGinnis

    Comments

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    Abbreviated Journal Title

    Adv.Exp.Med.Biol.

    Keywords

    Tubby mouse; Nanoceria; Thioredoxin; Oxidative stress and antioxidant; defense; PCR array; SOD1-DEFICIENT MICE; DEGENERATION; CELLS; NUCLEOREDOXIN; DYSFUNCTION; MECHANISM; STRESS; Biology; Medicine, Research & Experimental; Ophthalmology

    Abstract

    Oxidative stress is a node common to the causes and effects of various ocular diseases. We have shown that thioredoxin has neuroprotective effects on tubby photoreceptors. We also demonstrated that nanoceria (cerium oxide nanoparticles), which are direct antioxidants, have long-term effects on prevention of retinal degeneration in tubby mice. Here, using commercially available PCR array plates, we surveyed the regulation in expression of 89 oxidative stress-associated genes in the eyes of P12 tubby mice which are either intravitreally injected with nanoceria or in which the Trx gene is overexpressed. Our data demonstrate that nanoceria and Trx regulate the same group of genes associated with antioxidative stress and antioxidant defense.

    Journal Title

    Retinal Degenerative Diseases: Mechanisms and Experimental Therapy

    Volume

    801

    Publication Date

    1-1-2014

    Document Type

    Article

    Language

    English

    First Page

    829

    Last Page

    836

    WOS Identifier

    WOS:000350418200105

    ISSN

    0065-2598; 978-1-4614-3209-8; 978-1-4614-3208-1

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