Title
Nanoceria and Thioredoxin Regulate a Common Antioxidative Gene Network in tubby Mice
Abbreviated Journal Title
Adv.Exp.Med.Biol.
Keywords
Tubby mouse; Nanoceria; Thioredoxin; Oxidative stress and antioxidant; defense; PCR array; SOD1-DEFICIENT MICE; DEGENERATION; CELLS; NUCLEOREDOXIN; DYSFUNCTION; MECHANISM; STRESS; Biology; Medicine, Research & Experimental; Ophthalmology
Abstract
Oxidative stress is a node common to the causes and effects of various ocular diseases. We have shown that thioredoxin has neuroprotective effects on tubby photoreceptors. We also demonstrated that nanoceria (cerium oxide nanoparticles), which are direct antioxidants, have long-term effects on prevention of retinal degeneration in tubby mice. Here, using commercially available PCR array plates, we surveyed the regulation in expression of 89 oxidative stress-associated genes in the eyes of P12 tubby mice which are either intravitreally injected with nanoceria or in which the Trx gene is overexpressed. Our data demonstrate that nanoceria and Trx regulate the same group of genes associated with antioxidative stress and antioxidant defense.
Journal Title
Retinal Degenerative Diseases: Mechanisms and Experimental Therapy
Volume
801
Publication Date
1-1-2014
Document Type
Article
Language
English
First Page
829
Last Page
836
WOS Identifier
ISSN
0065-2598; 978-1-4614-3209-8; 978-1-4614-3208-1
Recommended Citation
"Nanoceria and Thioredoxin Regulate a Common Antioxidative Gene Network in tubby Mice" (2014). Faculty Bibliography 2010s. 5121.
https://stars.library.ucf.edu/facultybib2010/5121
Comments
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