Title

Physical working capacity at fatigue threshold (PWCFT) is associated with sarcopenia-related body composition and measures of functionality in older adults

Authors

Authors

N. S. Emerson; D. H. Fukuda; J. R. Stout; E. H. Robinson; W. P. McCormack; T. C. Scanlon; A. M. Warren; A. J. Wells; A. M. Gonzalez; G. T. Mangine; M. S. Fragala;J. R. Hoffman

Comments

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Abbreviated Journal Title

Arch. Gerontol. Geriatr.

Keywords

Aging; Neuromuscular function; Disability; Skeletal muscle index; NEUROMUSCULAR FATIGUE; MUSCLE STRENGTH; ELDERLY-MEN; QUALITY; DISABILITY; FITNESS; HEALTH; WOMEN; MASS; IMPAIRMENT; Geriatrics & Gerontology

Abstract

The relationship between PWCFT and common measures used to assess sarcopenia in older adults were examined. Fifty-eight older adults [age: 71.1 +/- 6.2 years; body mass index (BMI): 28.0 +/- 5.4 kg/m(2)] completed the testing procedures. Sarcopenia-related body composition was measured by dual-energy X-ray absorptiometry and participants performed a discontinuous cycle ergometry test to determine PWCFT. Functionality assessments included maximal isometric grip strength (GRIP) and sit-to-stand (STS) repetitions in 30 s. Muscle quality (MQ) was defined as GRIP relative to appendicular lean soft tissue (ALM), while skeletal muscle index (SMI) was defined as ALM/height(2). Pearson correlations were used to examine the relationships among dependent variables. PWCFT showed significant relationships with ALM (r = 0.57), SMI (r = 0.47), body fat percentage (BF%) (r = -0.50), GRIP (r = 0.49), and STS (r = 0.44). For follow-up analyses, study participants were categorized into low sarcopenia risk (n = 31) or high sarcopenia risk (n = 27) groups by SMI. Sarcopenia risk was associated with PWCFT [odds ratio (OR): 1.051, 95% confidence interval (CI): 1.016-1.087] and STS (OR: 1.305, CI: 1.060-1.607), but not GRIP (OR: 1.098, CI: 0.989-1.218). Using receiver-operator characteristic curve analysis, both PWCFT [area under the curve (AUC): 0.737, CI: 0.608-0.866, optimal cutoff: 37.5 W] and STS (AUC: 0.749, CI: 0.623-0.874, optimal cutoff: 12.5 repetitions) showed discriminative ability with regard to sarcopenia risk. The current data suggest that the neuromuscular fatigue threshold, as measured by PWCFT, is related to measures of body composition and function in older adults. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

Journal Title

Archives of Gerontology and Geriatrics

Volume

59

Issue/Number

2

Publication Date

1-1-2014

Document Type

Article

Language

English

First Page

300

Last Page

304

WOS Identifier

WOS:000341018300014

ISSN

0167-4943

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