Muscle quality index improves with resistance exercise training in older adults

    Authors

    M. S. Fragala; D. H. Fukuda; J. R. Stout; J. R. Townsend; N. S. Emerson; C. H. Boone; K. S. Beyer; L. P. Oliveira;J. R. Hoffman

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    Abbreviated Journal Title

    Exp. Gerontol.

    Keywords

    Sarcopenia; Power; Intervention; Aging; Elderly; Strength; Resistance; training; DWELLING ELDERLY-WOMEN; FUNCTIONAL STATUS; SKELETAL-MUSCLE; STRENGTH; AGE; SARCOPENIA; HEALTH; MEN; HYPERTROPHY; DIAGNOSIS; Geriatrics & Gerontology

    Abstract

    Introduction: Sarcopenia is currently best described as an age-related decline in skeletal muscle mass and function. However, no consensus exists as to how to best quantify muscle function in older adults. The muscle quality index (MQI) was recently recommended as an ideal evidence-based assessment of functional status in older adults. Nevertheless, the usefulness of MQI to assess physical function is limited by whether it is reflective of muscle qualitative changes to an intervention. Thus, the purpose of this investigation was to determine whether MQI changes in response to resistance exercise training and detraining and how such changes correspond to other recommended measures of physical function proposed by suggested definitions of sarcopenia. Methods: Twenty-five older adults (70.6 +/- 6.1 y; BMI = 28.1 +/- 5.4 kg . m(-2)) completed a 6-week resistance training program in a wait-list controlled, cross-over design. MQI was determined as power output from timed sit to stand (STS), body mass, and leg length. Gait speed, hand grip strength, get-up-and-go and lean body mass (LBM) were evaluated before and after exercise training and detraining. MQI and functional changes to training and detraining were evaluated with repeated measures ANOVA and clinical interpretations of magnitude based inferences. Results: Short term resistance training significantly and clinically improved MQI (203.4 +/- 64.31 to 244.3 +/- 82.92W), gait time (1.85 +/- 0.36 to 1.66 +/- 0.27 s) and sit to stand performance (13.21 +/- 2.51 to 11.05 +/- 1.58 s). Changes in LBM and hand grip strength were not significant or clinically meaningful. De-training for 6-weeks did not result in significant changes in any measure from post-training performance. (C) 2014 Elsevier Inc. All rights reserved.

    Journal Title

    Experimental Gerontology

    Volume

    53

    Publication Date

    1-1-2014

    Document Type

    Article

    Language

    English

    First Page

    1

    Last Page

    6

    WOS Identifier

    WOS:000333765200001

    ISSN

    0531-5565

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