Effects of beta-hydroxy-beta-methylbutyrate free acid and cold water immersion on post-exercise markers of muscle damage

    Authors

    A. M. Gonzalez; J. R. Stout; A. R. Jajtner; J. R. Townsend; A. J. Wells; K. S. Beyer; C. H. Boone; G. J. Pruna; G. T. Mangine; T. M. Scanlon; J. D. Bohner; L. P. Oliveira; M. S. Fragala;J. R. Hoffman

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    Abbreviated Journal Title

    Amino Acids

    Keywords

    Cytokines; C-reactive protein; Myoglobin; Recovery; HMB; Cryotherapy; C-REACTIVE PROTEIN; SKELETAL-MUSCLE; RESISTANCE EXERCISE; ECCENTRIC; EXERCISE; RECOVERY; PERFORMANCE; INTENSITY; INDEXES; SUPPLEMENTATION; CRYOTHERAPY; Biochemistry & Molecular Biology

    Abstract

    The aim of the current study was to examine the effects of cold water immersion (CWI) with and without the free acid form of beta-hydroxy-beta-methylbutyrate (HMB-FA) on markers of muscle damage following acute lower body resistance exercise. Forty recreationally resistance-trained men (22.3 +/- A 2.4 years) were randomly divided into one of the four groups: (1) Placebo (PL); (2) HMB-FA; (3) HMB-FA-CWI; (4) PL-CWI. HMB-FA groups ingested 3 g day(-1) and CWI groups submersed their lower body into 10-12 A degrees C water for 10-min post-exercise. No differences between groups were observed for CK; however, PL-CWI had significantly greater elevations in myoglobin 30-min post-exercise compared to HMB-FA (p = 0.009) and PL (p = 0.005), and HMB-FA-CWI was significantly greater than HMB-FA (p = 0.046) and PL (p = 0.028). No differences between groups were observed for IL-6 and IL-10, although CRP was significantly greater 24-h post-exercise for PL-CWI compared to HMB-FA-CWI (p = 0.02) and HMB-FA (p = 0.046). Only HMB-FA-CWI showed significantly (p = 0.02) greater improvements in average power per repetition. CWI appeared to elevate myoglobin compared to other groups, while HMB-FA may have attenuated the increase in CRP when combined with CWI. Nevertheless, HMB-FA or CWI treatments did not appear to provide benefit over PL for recovery. Instead, the combination of CWI and HMB-FA improved performance recovery compared to other groups.

    Journal Title

    Amino Acids

    Volume

    46

    Issue/Number

    6

    Publication Date

    1-1-2014

    Document Type

    Article

    Language

    English

    First Page

    1501

    Last Page

    1511

    WOS Identifier

    WOS:000336268800008

    ISSN

    0939-4451

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