Solution method for the transformed time-dependent Michaelis-Menten enzymatic reaction model

    Authors

    J. Math. Chem.

    Comments

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    Abbreviated Journal Title

    IEEE Trans. Device Mater. Reliab.

    Keywords

    Dynamic Michaelis-Menten model; Nonlinear dynamics; Stability; Enzyme; reactions; HOMOTOPY ANALYSIS METHOD; NONLINEAR DIFFERENTIAL-EQUATIONS; VISCOUS-FLOW; PROBLEMS; NON-NEWTONIAN FLUIDS; EMDEN-FOWLER TYPE; ANALYTIC SOLUTION; SERIES SOLUTIONS; APPROXIMATE SOLUTION; GENERAL-APPROACH; KINETICS; Chemistry, Multidisciplinary; Mathematics, Interdisciplinary; Applications

    Abstract

    The dynamic form of the Michaelis-Menten enzymatic reaction equations provides a time-dependent model in which a substrate S reacts with an enzyme E to form a complex C which is in turn converted into a product P and the enzyme E. In the recent paper [Mallory and Van Gorder in J Math Chem 52: 222-230, 2014], it was shown that this system of four nonlinear equations can be reduced to a single nonlinear differential equation, which is simpler to solve numerically than the system of four equations. Qualitative properties of solutions were discussed, and stability results were given. In the present paper, we apply the optimal homotopy analysis method to the solution of this problem in order to obtain quantitative results. To do so, we transform the governing equation into a form that is more amenable to analysis. From the homotopy solutions, we are then able to study the effects of the model parameters on the solutions to the dynamic Michaelis-Menten enzymatic reaction equations. The results demonstrate the accuracy and efficiency of the approach, with residual errors of 10-6-10-10 by considering relatively few iterations of the method. Therefore, the optimal homotopy analysis method is shown to be a rather useful tool for constructing analytical solutions to the dynamic Michaelis-Menten enzymatic reaction equations.

    Subjects

    R. Li; R. A. Van Gorder; K. Mallory;K. Vajravelu

    Volume

    52

    Issue/Number

    10

    Publication Date

    1-1-2014

    Document Type

    Article

    Language

    English

    First Page

    2494

    Last Page

    2506

    WOS Identifier

    WOS:000343754600003

    ISSN

    0259-9791

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